Molecular and genetic studies of <i>Fusarium</i> trichothecene biosynthesis: toward understanding the transcriptional regulatory mechanisms of trichothecene (<i>Tri</i>) genes
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چکیده
منابع مشابه
Biochemistry and Regulation of Trichothecene Toxin Biosynthesis in Fusarium
The trichothecenes are a large family of sesquiterpene epoxides that inhibit eukaryotic protein synthesis and thereby impairhuman and animal health. Several fungal species of the genus Fusarium and related generacan produce trichothecenes in agricultural crops and commodities. Interest in these toxins is due primarily to the discovery that trichothecene contamination ofhuman foods and animal fe...
متن کاملBiosynthesis of trichothecene mycotoxins in Fusarium culmorum cultures.
A high yielding production of the trichothecene mycotoxin 3-acetyldeoxynivalenol (3-AcDON) in cultures of Fusarium culmorum is described. By supplying [14C]acetate, 14C-labelled 3-AcDON suitable for further metabolic studies has been obtained. The pattern of labelling has been ascertained by using 13C-labelled acetate precursors, and is in line with established biosynthetic data. A second trich...
متن کاملVariation in Type A Trichothecene Production and Trichothecene Biosynthetic Genes in Fusarium goolgardi from Natural Ecosystems of Australia
Fusarium goolgardi, isolated from the grass tree Xanthorrhoea glauca in natural ecosystems of Australia, is closely related to fusaria that produce a subgroup of trichothecene (type A) mycotoxins that lack a carbonyl group at carbon atom 8 (C-8). Mass spectrometric analysis revealed that F. goolgardi isolates produce type A trichothecenes, but exhibited one of two chemotypes. Some isolates (50%...
متن کاملFusarium Tri4 encodes a multifunctional oxygenase required for trichothecene biosynthesis.
Fusarium graminearum and Fusarium sporotrichioides produce the trichothecene mycotoxins 15-acetyldeoxynivalenol and T-2 toxin, respectively. In both species, disruption of the P450 monooxygenase-encoding gene, Tri4, blocks production of the mycotoxins and leads to the accumulation of the trichothecene precursor trichodiene. To further characterize its function, the F. graminearum Tri4 (FgTri4) ...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
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ژورنال
عنوان ژورنال: JSM Mycotoxins
سال: 2020
ISSN: 0285-1466,1881-0128
DOI: 10.2520/myco.70-1-4